5-Amino-1MQ
Also called amino-1MQ, NNMT inhibitor
An enzyme blocker rather than a hormone.
The published research here is animal and laboratory work. The ranges below come from community-reported dosing and results — what people have settled on in practice, and what they report happening.
- Energy
- Fat loss & metabolic
The quick answer
An enzyme blocker rather than a hormone. It inhibits NNMT, an enzyme in fat tissue, and in mice that shifts how fat cells handle energy. Oral rather than injected, which is part of the appeal.
What it is not
No human trial exists. Not a GLP-1 and not comparable to one.
Why people use it
Reported as an energy and body-composition compound rather than an appetite one. People describe it as something they stack alongside a deficit, not something that creates one.
What people report using
These are ranges other people have reported running. They are here so you can see what has actually been done — they are not medical advice and not a recommendation for you.
People report running this anywhere from 50mg to 150mg, once daily.Where somebody sits in that range depends on what they are using it for and what they are starting from — the low end is a deliberate choice a lot of people make, not a half-hearted version of the high end.
Fat loss & metabolic
- How often
- Once daily
- Route
- oral
- Where this comes from
- Animal and lab research
Energy and endurance are the most common first reports, around weeks two to four.
What to expect, and when
Week 2-4: energy, described as steadier rather than higher. Week 6-12: body composition, gradual and in the context of a deficit. Nothing is reported in days.
Side effects, and what people do about them
Little consistent signal, which reflects how thin the experience base is rather than an absence of effects.
Go deeper
Open these only if you want them.
How it actually works
NNMT inhibitor.
More on the evidence
NNMT inhibitor. Mouse work only. No human trial.
What people report, in full
People run 5-Amino-1MQ alongside a deficit rather than instead of one, and the reports reflect that - steadier energy and better body composition over weeks, not a switch flipping. It is oral, which is most of its appeal in a category where everything else is an injection, and it is described as unusually uneventful to take.
The mechanism is the other half of the appeal and the community is genuinely interested in it: it blocks an enzyme (NNMT) that fat cells produce more of as they get larger, and blocking it appears to free up the cells' own metabolic machinery. That is a different lever from anything else on this list, and people say so - it turns up in stacking discussions specifically because it does not overlap with a GLP-1.
The honest note the community itself keeps making is that the striking results are from mice, that no human trial has been run, and that the reports available are from people who were also dieting and training. Nobody who has used it describes it as dramatic. What they describe is mild, gradual and easy to live with.
Worth knowing
This is the normal state of this category and it is not a black mark. It usually means nobody could patent the molecule tightly enough to fund a trial. It is not the same as having been tested and failed.
Sources and review
This record is built on what the wider community reports doing and experiencing, summarised above. No counted dataset has been attached to this compound yet — when one is published, it goes here with its numbers.
Neelakantan H, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol 2018. PMID 29155147.High-fat-diet obesity in mice.
These references were located by literature search and recorded as the primary sources behind this record. The publishers block automated retrieval, so they are pointers to the right papers rather than quotations we have checked line by line. They are replaced as we read them properly.
Last reviewed 2026-09-08.
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