CJC-1295 with DAC
Also called CJC1295, DAC:GRF
CJC-1295 is a stabilised copy of your own GHRH - the upstream signal that gives the pituitary permission to release growth hormone.
Studied in people, in small numbers. The ranges below lean mostly on community-reported dosing and results — what people run, and what they say happened.
- Longevity & anti-aging
- Recovery & injury
The quick answer
CJC-1295 is a stabilised copy of your own GHRH - the upstream signal that gives the pituitary permission to release growth hormone. The DAC version carries a small chemical anchor that lets it ride along on albumin in the blood, which is why it lasts most of a week instead of half an hour.
What it is not
Not growth hormone, and not interchangeable with the no-DAC version despite sharing a name.
Why people use it
🛏️ Steadier sleep across the whole week; 🩹 Recovery that does not dip between doses; 📅 A once- or twice-weekly rhythm people find easy to keep; 💪 Slow body-composition change over months
What people report using
These are ranges other people have reported running. They are here so you can see what has actually been done — they are not medical advice and not a recommendation for you.
- How often
- Once a week
- Route
- subcutaneous
- Evidence for this
- Small human studies
Sleep and recovery over the first few weeks; skin and body composition, where reported, over two to three months.
What to expect, and when
Week 1: sleep and a general sense of easier recovery; puffiness, if it is going to happen, shows up here too. Week 4-8: recovery and soreness. Month 3 onward: body composition, gradual.
Side effects, and what people do about them
Water retention and puffiness in the hands and face is the most reported effect, and it is the main reason people move to the no-DAC version. Tingling or numbness in the fingers turns up in people running it long. A head-rush in the first hour is common and brief.
Go deeper
Open these only if you want them.
How it actually works
A GHRH analogue carrying a Drug Affinity Complex that binds covalently to serum albumin, stretching half-life to roughly six to eight days. The consequence people actually feel: it lifts the baseline that pulses ride on rather than creating a discrete pulse. That is why it is dosed weekly, and why it is paired with a ghrelin-receptor agonist rather than run alone.
More on the evidence
Small human pharmacokinetic studies only.
The case against
Human trials exist but were run for GH deficiency and pharmacokinetics, not body composition in healthy adults. It raised GH and IGF-1 reliably - that part is solid ground. What that does for a healthy forty-year-old was not the question anyone asked.
What people report, in full
The single most important thing the community says about CJC-1295 is that the name means two different things and people constantly conflate them. With DAC it is in you for most of a week; without DAC it is gone in about half an hour. Almost every confused report - "I felt nothing", "I was bloated the entire time" - traces back to somebody buying one and following a protocol written for the other. The DAC version is described as a background rather than an event: people say they sleep better in a general way rather than pointing at a particular night. Because it holds GH slightly raised all week instead of in pulses, the puffiness reports are almost all from DAC users, and the standard community fix is to switch to no-DAC and dose at night. Long-run users describe it as the one you pick if you cannot face daily injections and will accept a little water in exchange.
Sources and review
https://pubmed.ncbi.nlm.nih.gov/16352683/
https://pubmed.ncbi.nlm.nih.gov/17018654/
Last reviewed 2026-09-08.
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Still not sure?
Ask it the way you would ask a person. Follow-up questions are the point — it remembers what you already said.
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