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Anti-Aging & Longevity

CJC-1295 without DAC

Also called Mod GRF 1-29, modified GRF

The same GHRH signal without the albumin anchor - in and out in about half an hour.

Where this answer comes fromSmall human studies

Studied in people, in small numbers. The ranges below lean mostly on community-reported dosing and results — what people run, and what they say happened.

The quick answer

The same GHRH signal without the albumin anchor - in and out in about half an hour. That short window is the point: it produces a pulse shaped like the one your body makes on its own, rather than a raised baseline.

What it is not

Not the DAC version. A protocol written for one does not transfer to the other.

Why people use it

😴 Sleep depth, the most consistent report; 💧 Far less water retention than the DAC version; 🩹 Recovery; 🎯 A pulse pattern closer to the natural one

What people report using

These are ranges other people have reported running. They are here so you can see what has actually been done — they are not medical advice and not a recommendation for you.

Standard — 100mcg, before bed100mcg

Recovery & anti-aging

How often
1–3 times daily
Route
subcutaneous
Where this comes from
Small human studies

Sleep depth early, recovery over weeks.

What to expect, and when

Week 1-2: sleep, vivid dreams, the evening flush. Week 4-8: recovery. Month 3 onward: composition, modest.

Side effects, and what people do about them

Head fullness in the first minutes. Much less puffiness than DAC. A flush in the face is common in the pairing, and the community explanation for it is the right one: it is a histamine response, not a measure of potency.

Go deeper

Open these only if you want them.

How it actually works

Modified GRF(1-29): a four-substitution GHRH fragment stable enough to survive injection but cleared within roughly thirty minutes. Paired with a ghrelin-receptor agonist it produces a sharp, short GH pulse and then returns to baseline, which is the physiological pattern.

More on the evidence

Short-acting GHRH analogue. Small human PK work.

What people report, in full

This is the version experienced users converge on, and the reason they give is always the same: pulses, not a plateau. People who ran DAC and moved across describe the water coming off within a week or two while the sleep effect stayed. It is dosed at night on an empty stomach, and the empty stomach is not a nicety - the recurring failure story is someone dosing after a meal and concluding the vial was fake. Almost nobody runs it alone; it is the CJC half of the CJC-plus-Ipamorelin pairing and the discussion treats that pair as one thing. The face flush comes up constantly and the community handles it well: histamine, a few minutes, not a sign of strength.

Worth knowing

The human testing was for a different purpose than people use it for here

The trials are real. They were not asking the question most people are asking when they come looking for this one.

The case against

Same trial picture as the DAC version - studied for GH deficiency and pharmacokinetics, not for body composition in healthy adults.

Sources and review

What people report

This record is built on what the wider community reports doing and experiencing, summarised above. No counted dataset has been attached to this compound yet — when one is published, it goes here with its numbers.

References

Wilton P, et al. Pharmacokinetics of GHRH(1-29)-NH2 and stimulation of growth hormone secretion in healthy subjects. Acta Paediatr 1993. PMID 8329825.Human data exist for the unmodified parent peptide. No human trial of the tetrasubstituted modified GRF(1-29) was found.

These references were located by literature search and recorded as the primary sources behind this record. The publishers block automated retrieval, so they are pointers to the right papers rather than quotations we have checked line by line. They are replaced as we read them properly.

Last reviewed 2026-09-08.

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