Sermorelin
Also called Geref, GHRH 1-29
Sermorelin is the original GHRH fragment - the first twenty-nine amino acids of the natural hormone, which is the part that does the work.
This one has been through full clinical trials and is an approved medicine somewhere in the world. The ranges below are drawn from those trials and from what the community reports using.
- Longevity & anti-aging
The quick answer
Sermorelin is the original GHRH fragment - the first twenty-nine amino acids of the natural hormone, which is the part that does the work. It was an approved medicine, used in children for years, before it left the market for commercial reasons rather than safety ones.
What it is not
Not growth hormone, and not stronger than the modern analogues. Its case is the record, not the punch.
Why people use it
😴 Sleep quality, the most reported effect; 🕰️ A long human safety record, including in children; 🩹 Recovery; ⚖️ Self-limiting, because the body's own brake still works
What people report using
These are ranges other people have reported running. They are here so you can see what has actually been done — they are not medical advice and not a recommendation for you.
People report running this anywhere from 200mcg to 300mcg, nightly, 5 nights a week.Where somebody sits in that range depends on what they are using it for and what they are starting from — the low end is a deliberate choice a lot of people make, not a half-hearted version of the high end.
Recovery & anti-aging
- How often
- Nightly, 5 nights a week
- Route
- subcutaneous
- Where this comes from
- Approved medicine
Deeper sleep within the first week or two; recovery and skin over a couple of months.
What to expect, and when
Week 1-2: sleep. Month 2: recovery. Month 3 onward: composition, understated.
Side effects, and what people do about them
Injection-site redness, a brief flush, an occasional head-rush. Regarded as the gentlest member of the family.
Go deeper
Open these only if you want them.
How it actually works
GHRH(1-29). Binds the pituitary GHRH receptor and triggers a GH pulse, then clears in ten to twenty minutes. It leaves the feedback loop intact - somatostatin still shuts the pulse down - which is why it is described as difficult to overshoot.
More on the evidence
Was an approved diagnostic/therapeutic agent; withdrawn from the US market commercially, not for safety. VERIFY.
What people report, in full
Sermorelin is what people recommend to someone nervous about starting, and the reason given is always the same: it was a real approved drug given to children for years, so the human safety picture is not a guess. The reported effects are described as real but understated - better sleep in the first couple of weeks, easier recovery by the second month, and not much else that is dramatic. Experienced users tend to say they moved on to the CJC pairing for a stronger effect and fewer injections; the ones who stayed say they stayed because nothing about it ever bothered them. Evening dosing away from food is the universal convention here too, and the "I felt nothing" reports trace back to the same cause.
Worth knowing
Withdrawn from the US market in 2008 by its manufacturer for commercial reasons. It worked; it stopped selling.
Sources and review
This record is built on what the wider community reports doing and experiencing, summarised above. No counted dataset has been attached to this compound yet — when one is published, it goes here with its numbers.
These references were located by literature search and recorded as the primary sources behind this record. The publishers block automated retrieval, so they are pointers to the right papers rather than quotations we have checked line by line. They are replaced as we read them properly.
Last reviewed 2026-09-08.
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Still not sure?
Ask it the way you would ask a person. Follow-up questions are the point — it remembers what you already said.
Ask about Sermorelin